Aprepitant

Aprepitant Aprepitant :

(1R,2R,3S)-Aprepitant ; 5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one ; CAS : 170729-80-3 ; C23H21F7N4O3 ; MW: 534.43 ;
Aprepitant EP Impurity A Aprepitant Impurity A :

Desfluoro Aprepitant ; 5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-phenyl morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one ; CAS : 170729-76-7 ; C23H22F6N4O3 ; MW: 516.44 ;
Aprepitant EP Impurity B

Aprepitant Impurity B:

4-Defluoro-3-(p-fluorophenyl)aprepitant ;

5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(Trifluoromethyl) phenyl]ethoxy]-3-(4′-fluoro biphenyl-3-yl) morpholin-4-yl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one and enantiomer ; C29H25F7N4O3 ; MW: 610.52 ;
Aprepitant EP Impurity C Aprepitant Impurity C:

Aprepitant para-Biphenyl Impurity ; 4-Defluoro-4-(p-fluorophenyl)aprepitant ;

5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(Trifluoromethyl)phenyl]ethoxy]-3-(4′-fluoro biphenyl-4-yl) morpholin-4-yl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one and enantiomer ; C29H25F7N4O3 ; MW: 610.52 ;
Aprepitant EP Impurity D Aprepitant Impurity D:

 (1S,2S,3R-Aprepitant ; ent-Aprepitant ; 3-[[(2S,3R)-2-[(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro phenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one ; CAS : 172822-29-6 ; C23H21F7N4O3 ; MW: 534.43 ;
Aprepitant EP Impurity E Aprepitant Impurity E:

(R,R,R)-Aprepitant ; 3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro phenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one ; CAS : 1148113-53-4 ; C23H21F7N4O3 ; MW: 534.43 ;
Aprepitant N-Oxide

Aprepitant N-Oxide:

5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)-4-oxido-morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one ; CAS : 172673-23-3 ;  C23H21F7N4O4 ; Mol. Wt.: 550.43 ;