Escitalopram – Analyticsstanza

EsCitalopram Impurity A :

Citalopram Amide ; 1-(3-(Dimethylamino)propyl)-1-(4\\\’-fluorophenyl)-1,3-dihydro isobenzo furan-5-carboxamide ; CAS : 64372-56-1 ; C20H23FN2O2 ; Mol. Wt.: 342.41 ;

EsCitalopram Impurity B :

3-Hydroxy Citalopram ; 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-3-hydroxy-1,3-dihydro isobenzofuran-5-carbonitrile ; CAS : 1332724-03-4 (oxalate salt) ; 411221-53-9 (base) ; C20H21FN2O2 (oxalate salt) ; Mol. Wt.: 340.39 ;

EsCitalopram Impurity C:

3-Oxo Citalopram Oxalate ; 3-[3-(Dimethylamino)-1-propyl](4-fluorophenyl)-6-cyano-1(3H)-isobenzofuranone oxalate ; CAS : 372941-54-3 (base) ; C22H21FN2O6 ;

Mol. Wt.: 428.41 ;

EsCitalopram Impurity D :

N-Desmethyl Citalopram HCl ; 1-(4\\\’-Fluorophenyl)-1-(3-(methylamino)propyl)-1,3-dihydro isobenzo furan-5-carbonitrile hydrochloride ; CAS : 144025-14-9 (HCl salt) ; 1188264-72-3 (HBr salt) ; C19H20ClFN2O (HCl salt) ; Mol. Wt.: 346.83 (HCL salt) ;

Escitalopram Impurity E:

Citadiol HBr ; Citalopram Dihydroxy Impurity ; CAS : 103146-26-5 (HBr salt) ; 103146-25-4 (base) ; C20H28BrFN2O2 (HBr Salt) ; MW: 427.35 ;

EsCitalopram Impurity F :

(1RS)-1-[3-(Dimethylamino)propyl]-1-hydroxy-1,3-dihydroisobenzofuran-5-carbonitrile ; C14H18N2O2 ; Mol. Wt.: 246.30 ;

EsCitalopram Impurity G:

4-(Dimethylamino)-1-[(1RS)-1-[3- (dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2- benzofuran-5-yl]butan-1-one ; CAS : 1329745-98-3 (base) ;

C25H35FN2O2 ; MW: 412.54 ;

EsCitalopram Impurity H:

Citalopram N-Oxide ; 1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzo furan-5-carbonitrile-N-oxide ; CAS : 63284-72-0 ;

C20H21FN2O2 ; MW: 340.39 ;

EsCitalopram Impurity I:

4-[(1Z)-4-(Dimethylamino)-1-(4-fluorophenyl)but-1-en-1-yl]-3-(hydroxymethyl)benzonitrile ;

C20H25FN2O (base) ; Mol. Wt.: 328.42 ; C22H27FN2O5 (oxalate salt) ; Mol. Wt.: 418.46 ;

EsCitalopram Impurity K :

Citalopram R-Isomer ; (R)-(-)-1-(3-Dimethylaminopropyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile oxalate ; CAS : 219861-53-7 (oxalate salt) ; 128196-02-1 (base) ; C22H23FN2O5 ; MW: 414.43 ;

EsCitalopram Impurity L:

Citalopram Desfluoro Impurity ; (1RS)-1-[3-(Dimethylamino)propyl]-1-phenyl-1,3-dihydroisobenzofuran-5-carbonitrile oxalate ; CAS : 1346617-30-8 ;

C22H24N2O5 ; Mol. Wt.: 396.44 ;

EsCitalopram Impurity M:

Citalopram Carboxylic Acid Impurity ; (1RS)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzo furan-5-carboxylic acid ;

C20H22FNO3 ; Mol. Wt.: 343.39 ;

EsCitalopram Oxalate:

Citalopram S-Isomer Oxalate ; CAS : 219861-08-2 ;

C22H27FN2O5 ; MW: 418.46 ;