Levothyroxine – Analyticsstanza

Levothyroxine Acetamide Impurity :

2-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5- iodophenyl)acetamide ; CAS : 176258-88-1 ; C14H9I4NO3 ; MW: 746.84

Levothyroxine beta-Hydroxy Impurity:

O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-beta-hydroxy-L-tyrosine ; CAS : 107849-54-7 ; C15H11I4NO5 ; MW: 792.87 ;

Levothyroxine D-Isomer :

(2R)-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl) propanoic acid ; CAS : 51-49-0 ; C15H11I4NO4 ; MW: 776.87 ;

Levothyroxine Impurity A :

Liothyronine ; (2S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid ; CAS : 6893-02-3 ; C15H12I3NO4 ; MW: 650.97 ;

Levothyroxine Impurity B:

Levothyroxine Chloro Impurity ; 3-Chloro Thyroxine ; (2S)-2-Amino-3-[4-(3-chloro-4-hydroxy-5-iodophenoxy)-3,5-diiodophenyl] propanoic acid ; C15H11ClI3NO4 ; MW: 685.42 ;

Levothyroxine Impurity C :

Triiodothyroacetic acid ; [4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid ; CAS : 51-24-1 ; C14H9I3O4 ; MW: 621.93 ;

Levothyroxine Impurity D :

; Tetraiodothyroacetic acid ; [4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic acid ; CAS : 67-30-1 ; C14H8I4O4 ; MW: 747.83 ;

Levothyroxine Impurity E :

Diiodothyronine ; (2S)-2-Amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]-propanoic acid ; CAS : 1041-01-6 ; C15H13I2NO4 ; MW: 525.08 ;

Levothyroxine Impurity F :

O-(4-Hydroxy-3,5-diiodophenyl)thyroxine ; (2S)-2-Amino-3-[4-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenoxy]-3,5-diiodophenyl]propanoic acid ; CAS : 911661-90-0 ; C21H13I6NO5 ; MW: 1120.76 ;

Levothyroxine Impurity H :

Levothyroxine Benzoic Acid Impurity ; 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzoic acid ; CAS : 2055-97-2 ; C13H6I4O4 ; MW: 733.80 ;

Levothyroxine Impurity I:

4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzaldehyde ; CAS : 2016-06-0 ; C13H6I4O3 ; MW: 717.80 ;

Levothyroxine Impurity J:

(2S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl] propanoic acid ; CAS : 4604-41-5 ; C15H13I2NO4 ; MW: 525.08 ;

Levothyroxine Impurity K:

(2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl] propanoic acid ; CAS : 5817-39-0 ; C15H12I3NO4 ; MW: 650.97 ;

Levothyroxine Ethyl Ester :

Ethyl 2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo phenyl) propanoate ; CAS : 76353-71-4 ; C17H15I4NO4 ; MW: 804.92 ;

Levothyroxine Hydroxyphenoxy Aldehyde Impurity :

3,5-Diiodo Thyroaldehyde ; 4-(4-Hydroxy-phenoxy)-3,5-diiodobenzaldehyde ; CAS : 2828-49-1 ;C13H8I2O3 ;
Mol. Wt.: 466.01 ;

Levothyroxine Methoxyphenoxy Aldehyde Impurity:

3,5-Diiodo Thyroaldehyde Methyl Ether ; 4-(4-Methoxyphenoxy)-3,5-diiodobenzaldehyde ; CAS : 69240-57-9 ; C14H10I2O3 ;

Mol. Wt.: 480.04 ;

Levothyroxine Methyl Ester :

Methyl 2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo phenyl) propanoate ; CAS : 32180-11-3 ; C16H13I4NO4 ; MW: 790.9 ;

Levothyroxine Monochloro Impurity:

(S)-2-Amino-3-[3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl] propanoic acid ; C15H11ClI3NO4 ; MW: 685.42 ;

Levothyroxine N-Acetyl Impurity:

N-Acetyl-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine ; CAS : 26041-51-0 ; C17H13I4NO5 ; MW: 818.91 ;

Levothyroxine N-Formyl Impurity :

N-Formyl-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine ; CAS : 671235-41-9 ; C16H11I4NO5 ; MW: 804.88 ;

Levothyroxine N-Methylamide:

(S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-N-methylpropanamide ; C16H14I4N2O3 ; MW: 789.91 ;

Levothyroxine O-Methyl Amine Impurity :

O-Methyl-T4-Amine (USP) ; 2-[4-(3,5-Diiodo-4-methoxyphenoxy)-3,5-diiodophenyl]ethanamine ; C15H13I4NO2 ; MW: 746.89 ;

Levothyroxine Sodium:

Sodium 2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo phenyl) propanoate pentahydrate ; CAS : 25416-65-3 (monohydrate) ; 55-03-8 (pentahydrate) ; 51-48-9 (base) ; C15H20I4NNaO9 ; Mol. Wt.: 888.93 ;

Levothyroxine T4-Hydroxyacetic Acid Impurity:

2-Hydroxy-2-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)acetic acid ; CAS : 67-30-1 ; C14H8I4O5 ; MW: 763.83 ;